BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS
The virus-induced signaling adaptor protein VISA (also known as MAVS, ISP-1, Cardif) is a critical adaptor protein in the innate immune SHAMPOO UNSCENTED response to RNA virus infection.Upon viral infection, VISA self-aggregates to form a sizeable prion-like complex and recruits downstream signal components for signal transduction.Here, we discover